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Actonel ® Information

Symptoms of bone death in the jaw include:

pain;
swelling;
infection of the gums;
loosening of the teeth;
poor healing of the gums;
numbness or a feeling of heaviness in the jaw; and
exposed bone.

Osteonecrosis of the jaw (ONJ) is a condition in which part of the jaw bone is no longer alive and cannot regenerate itself due to a lack of blood supply. Most commonly in the past, patients developed ONJ after bone trauma, such as a tooth extraction. Rather than healing, the bone begins to die. In some cases, the bone becomes exposed, which can lead to serious infection and fracture. In extreme cases, surgery is required to remove the dead bone.

The most common signs and symptoms of ONJ include pain, soft-tissue and jaw swelling, loosening of teeth, drainage, exposed bone, and infection. Numbness, heaviness and other sensations in the jaw may also occur in some individuals. In order to diagnose ONJ, doctors may perform panoramic and tomographic imaging. They may also take microbial cultures and tissue biopsies in order to rule out other kinds of infections. Early detection of ONJ is imperative to preserving the jawbone.

Actonel ® is a type of drug known as bisphosphonates. Recently a link has been found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw (ONJ). This important discovery clearly shows that Actonel ® side effects may include osteonecrosis of the jaw.

The discovery, published in the Journal of Oral and Maxillofacial Surgeons, prompted both the US, Food and Drug Administration (FDA) and Novartis, the manufacturer of bisphosphonates used in cancer chemotherapy, to issue a warning to health care professionals on September 24, 2004. The warning letter contained information about bisphosphonates and the risks of osteonecrosis in the jaw.

Bisphosphonates are commonly used in tablet form such as Actonel® to prevent and treat osteoporosis in post-menopausal women. Stronger forms of bisphosphonates are commonly used in the management of advanced cancers that have metastasized to the bone, where the disease often causes bone pain and possibly even fractures. Several cancers can involve or metastasize to the bone, including lung cancer, breast cancer, prostate cancer, multiple myeloma, and others. When bisphosphonates are given in cancer chemotherapy, the drugs are given intravenously, and usually for longer periods of time.

If you have been injured by Actonel ® side effects you may be entitled to compensation. For more information about your legal rights

For additional information about ONJ, click here

If you or a loved one have taken Fosamax and suffered from necrosis of the jawbone, Osteonecrosis of the Jaw (ONJ) or other jaw bone problems or side effects, you may be due compensation.

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