Paget's Disease Drug Side Effects

Urgent medical-dental alert for people who took      
FOSAMAX ® , AREDIA ® or ZOMETA ®

These drugs have been linked to the catastrophic side effects
 “DEAD JAW” (Osteonecrosis of the jaw)
& other severe side effects

If you or a loved one has been taking any of these “Bisphosphonates” for Osteoporosis,
Cancer, Hypercalcemia, Paget's Disease, or Multiple Myeloma
& you have experienced side effects,
you must act now!

    YOU MAY DESERVE COMPENSATION!
for Paget's Drug Side Effects

Contact today the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly
or email us at
info@mpowelllaw.com

www.MPowellLaw.com

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

Paget's Disease Information

Overview

Paget's disease of bone is a condition that affects the process by which your body produces new material to keep your bones strong and healthy. The disease is named after a mid-19th-century English surgeon, Sir James Paget, who also identified Paget's disease of the breast. Other than sharing a name, however, the two conditions are unrelated.

Even after you've reached your full height, your bones don't stop growing. Bone is living tissue engaged in a continual process of renewal. During this constant process called remodeling, old bone is removed and replaced by new bone. Paget's disease disrupts this process. Early in the course of the disease, old bone starts breaking down faster than new bone can be built. Over time, your body responds by generating new bone at a faster than normal rate. This rapid remodeling produces bone that's softer and weaker than normal bone and can lead to bone pain, deformities and fractures.

Paget's disease most commonly affects your skull, spine and the bones in your arms, legs and pelvis. The disease may affect only one or two areas of your body, or may be widespread. You may not need treatment if you don't have symptoms. Treatments may involve medications and surgery.

 Signs and Symptoms

Paget's disease affects each person differently. Most people with Paget's disease have no symptoms. The most common symptom is pain in the areas of your body affected by Paget's. Affected areas may include:

• Bones. Pain in the affected bones is the most common symptom of Paget's disease. Your pain may be constant, aching and deep, and may be most severe at night.
• Joints. Paget's disease may damage the cartilage lining the joints near your affected bones. This wear and tear often leads to osteoarthritis in your affected joints, a condition that may cause pain, swelling and stiffness, especially after use.
• Nerves. Enlarged bones can compress your spinal cord or the nerves exiting your brain and spinal cord. Pain resulting from nerve compression is more severe than the bone pain associated with Paget's. The location of the pain caused by nerve compression depends on the nerve that's affected. You may notice pain radiating from your lower back into your legs (sciatica) if the lower region of your spine is affected. Pressure on a nerve can also cause numbness, tingling, weakness, hearing loss and double vision.

Other signs and symptoms of Paget's disease may include:

• Warmth in your skin over the affected area
• Neurologic problems, such as hearing loss, headache and rarely, vision loss
• Bone deformities, such as bowlegs and enlarged head size
• Fractures
  
  Causes
  Scientists haven't identified a cause of Paget's disease, though they have discovered several genes that appear to be linked to the disorder. Some scientists believe Paget's is related to a viral infection in your bone cells that may be present for many years before symptoms appear. Hereditary factors seem to influence whether you're susceptible to the disease.
  
  Risk Factors
  Age and heredity are the only known risk factors for Paget's disease. Occasionally, the disease runs in families. People older than 40 are the most likely to develop Paget's disease. Men and women are affected at similar rates.
  
  
  
   

Paget's Disease Drug Side Effects Information

 Zometa and Fosamax ( generic name - Alendronate ) is a type of drug known as bisphosphonates. Recently a side effect link has been found between bisphosphonates and a serious bone disease called osteonecrosis of the jaw ( ONJ ). This important discovery clearly shows that Zometa side effects may include osteonecrosis of the jaw, a serious side effect.

The discovery, published in the Journal of Oral and Maxillofacial Surgeons, prompted both the US, Food and Drug Administration ( FDA ) and Novartis, the manufacturer of bisphosphonates used in cancer chemotherapy and hypercalcemia, to issue a warning to health care professionals on September 24, 2004. The warning letter contained information about bisphosphonates and the risks of osteonecrosis in the jaw.

Stronger forms of bisphosphonates are commonly used in the management of advanced cancers that have metastasized to the bone, where the disease often causes bone pain and possibly even fractures. Several cancers can involve or metastasize to the bone, including lung cancer, breast cancer, prostate cancer, multiple myeloma, and others. When bisphosphonates are given in cancer chemotherapy, the drugs are given intravenously, and usually for longer periods of time.

If you or a loved one have taken Fosamax and have been injured as a result of Fosamax side effects such as osteonecrosis of the jaw contact today the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly
or email us at
info@mpowelllaw.com

www.MPowellLaw.com

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
.
.

Osteonecrosis of the Jaw
Osteonecrosis of the jaw ( ONJ ) is a condition in which the bone tissue in the jaw fails to heal after minor trauma such as a tooth extraction, causing the bone to be exposed. The exposure can eventually lead to infection and fracture and may require long-term antibiotic therapy or surgery to remove the dying bone tissue. Experts say that prevention and early treatment of individuals using bisphosphonates such as Fosamax is extremely important in preserving the jaw bone. Individuals using Fosomax or other bisphosphonates should attempt to avoid tooth extractions and other major dental work while on the drugs.

Although most cases of osteonecrosis of the jaw related to Fosamax side effects have occured after dental work several cases have been reported to occur without any prior dental work. If you are currently taking Fosamax you may be at risk of developing osteonecrosis. If you have been injured by Fosamax side effects you may be entitled to compensation. For more information about your legal rights contact the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly
or email us at
info@mpowelllaw.com

www.MPowellLaw.com

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212

More Pagets Disease Drug Side Effects Articles

 Zometa Jaw Bone Injury Awareness Program Should Be Enhanced ...  Mar 9, 2005
Dissemination of Novartis’ “Dear Doctor� letters for Zometa and Aredia concerning osteonecrosis of the jaw side effects risk should be extended to dentists, members ... - FDA Advisory Committee

Drug linked to death of jawbone side effects  Mar 13, 2005
Most were cancer patients who had received the intravenous bisphosphonates Zometa or Aredia or both for excessive calcium in their blood or bone tumors. ..Pagets. - USA Today

Novartis Sees Jaw Damage in Cancer Drug Patients  Mar 4, 2005
A Food and Drug Administration official said there was a "highly plausible" sign the cases were related to the drugs, Zometa and Aredia. ... - Reuters

Patients 'distressed' at switch to cheaper cancer drug  Mar 10, 2005
Van't Hof and the son and daughter of Mrs Borich describing the distress of the patients at having their chemotherapy changed last month from Zometa to Aredia ..side effects. - New Zealand Herald,

Bisphosphonates Can Cause Side Effects Problems in Jaw  Mar 15, 2005
...of the jaw (ONJ), particularly in patients undergoing a dental procedure while taking an intravenous bisphosphonate such as Aredia or Zometa and other cancer ... - Cancerpage.com,

Bisphosphonate Osteonecrosis May Be Class Effect, FDA Safety ...  Mar 3, 2005
ODS conducted a post-marketing safety review of the approved bisphosphonates Novartis’ Zometa (zoledronic acid) and Aredia (pamidronate), Merck’s Fosamax ... - FDA Advisory Committee

Cancer drugs stopped mid-treatment  Mar 10, 2005
On February 9, without explanation or informed consent, she was told that the drug Zometa, which was helping her fight cancer, would be stopped. ..side effects. - Scoop.co.nz (press release),

Questions & Answers for Oral Answer 10 March 2005  Mar 9, 2005
I am advised by Dr Nigel Murray of the board that the change made for the treatment Mrs Borich received as part of her cancer treatment, from Zometa to Aredia ..side effects. - Scoop.co.nz (press release),

Cytogen Corporation Provides QUADRAMET(R) Clinical Development and ...  Mar 17, 2005
University of Maryland in Baltimore evaluating the potential benefits of combination treatments including QUADRAMET and zoledronic acid (Zometa®) side effects in patients ... - Yahoo News (press release)  Pagets disease

Cytogen Corporation Provides QUADRAMET(R) Clinical Development and ...  Mar 17, 2005
...at the University of Maryland in Baltimore evaluating the potential benefits of combination treatments including QUADRAMET and zoledronic acid (Zometa(R)) in ... - PR Newswire (press release)

IMS Health annonce une croissance de 7 % de ses ventes mondiales ...  Mar 9, 2005
..."Today, there are seven anti-cancer drugs -- MabThera(R), Glivec(R), Eloxatine(R), Gemzar(R), Casodex(R), Taxotere(R) and Zometa(R) -- that have achieved ... - Le Revenu,

ADRAC : bisphosphonates and osteonecrosis of the jaw  Mar 9, 2005
Most of the cases have occurred following intravenous Pamidronate ( Aredia, Pamisol ) and/or Zoledronate/Zoledronic Acid ( Zometa ) therapy for malignancy, but ... - Xagena.it,

Drug linked to death of jawbone  14 Mar 2005
Most were cancer patients who had received the intravenous bisphosphonates Zometa or Aredia or both for excessive calcium in their blood or bone tumors. side effects... - USA Today

Zometa Jaw Bone Injury Awareness Program Should Be Enhanced ...  Mar 9, 2005
Dissemination of Novartis’ “Dear Doctor� letters for Zometa and Aredia concerning osteonecrosis of the jaw risk should be extended to dentists, members ... - FDA Advisory Committee

Cancer drugs stopped mid-treatment  Mar 10, 2005
On February 9, without explanation or informed consent, she was told that the drug Zometa, which was helping her fight cancer, would be stopped. ... - Scoop.co.nz (press release),

Patients 'distressed' at switch to cheaper cancer drug  Mar 10, 2005
Van't Hof and the son and daughter of Mrs Borich describing the distress of the patients at having their chemotherapy changed last month from Zometa to Aredia ... - New Zealand Herald,

Jaw Osteonecrosis Associated With Bisphosphonates in Some Cancer ...  Mar 7, 2005
A Food and Drug Administration official said there was a "highly plausible" sign the cases were related to the drugs, Zometa (zoledronic acid) and Aredia ... - Medscape (subscription) pagets disease

Bisphosphonate Osteonecrosis May Be Class Effect, FDA Safety ...  Mar 3, 2005
ODS conducted a post-marketing safety review of the approved bisphosphonates Novartis’ Zometa (zoledronic acid) and Aredia (pamidronate), Merck’s Fosamax ... - FDA Advisory Committee

Questions & Answers for Oral Answer 10 March 2005  Mar 9, 2005
I am advised by Dr Nigel Murray of the board that the change made for the treatment Mrs Borich received as part of her cancer treatment, from Zometa to Aredia ... - Scoop.co.nz (press release),

Postcode lottery over prostate cancer drug  Feb 25, 2005
The drug Zometa, which is used for patients whose cancer has spread to the bones, has not been approved for use in Scotland, despite being available in England ... - Scotsman,

Modified Taxotere® Regimen Effective for Advanced Prostate Cancer  Feb 25, 2005
Researchers from Greece have reported that the treatment combination consisting of Taxotere® (docetaxel), estramustine (Emcyt®) and Zometa® (zoledronic acid ... - Cancer Consultants (press release),

IMS Health annonce une croissance de 7 % de ses ventes mondiales ...  Mar 9, 2005
..."Today, there are seven anti-cancer drugs -- MabThera(R), Glivec(R), Eloxatine(R), Gemzar(R), Casodex(R), Taxotere(R) and Zometa(R) -- that have achieved ... - Le Revenu,

ADRAC : bisphosphonates and osteonecrosis of the jaw  Mar 9, 2005
Most of the cases have occurred following intravenous Pamidronate ( Aredia, Pamisol ) and/or Zoledronate/Zoledronic Acid ( Zometa ) therapy for malignancy, but ... - Xagena.it,

Amgen's AMG-162 for treatment of osteoporosis will become a ...  Feb 23, 2005
..."Much of the growth will be due to the launch of new bisphosphonates, including Roche's Boniva/Bonviva (ibandronate), Novartis's Zometa (zoledronate), and ... - News-Medical.net,

A mission that  Feb 18, 2005
Bocala's care requires daily amounts of pain management, a monthly IV-drip of Zometa to strengthen her bones, and bone and CAT scans every three months to ... - OregonLive.com,



Other resources:
Zometa archived articles: Zometa archive
Government Links for Zometa: Zometa resources from the U.S. government
Academic links for Zometa: Zometa academic resources
Zometa Old archives: Zometa archive
Zometa 2003 articles: Zometa archive

Zometa Side Effects Warning - Consumers May Deserve Compensation  Apr 26, 2005
...(PRWEB) April 27, 2005 -- Fosamax Side Effects Warning - Fosamax ( generic name - Alendronate ) is a type of drug known as bisphosphonates. ... - Emediawire (press release),

 Link found between bisphosphonates(Fosamax, Zometa, and Aredia) and a serious bone disease ...

Link found between Fosamax and Zometa bisphosphonates and a serious bone disease ...

... drug and a serious bone disease called osteonecrosis of the jaw (ONJ). ... were struck by a cluster of cancer patients with necrotic lesions in the jaw ... www.news-medical.net/print_article.asp?id=6844 - 13k - Cached - Similar pages

Doctors link biphosphonate drugs(Fosamax,Zometa, and Aredia) for osteoporosis and cancer to ...

... drug and a serious bone disease called osteonecrosis of the jaw. ... they were struck by a cluster of cancer patients with necrotic lesions in the jaw ... psa-rising.com/med/side_effects/osteo-necrosis.htm - 10k - Cached - Similar pages

Calcium and Vitamin D Fail in Fracture Prevention  29 Apr 2005
These include agents such as Fosamax (alendronate), Zometa (zoledronate), Boniva (ibandronate), Aredia (pamidronate), Didronel (etidronate), and Actonel ... - MedPage Today,

 Steroid use: Balancing the risks and benefits  Apr 27, 2005
And taking calcium and vitamin D supplements and prescription bisphosphonates, such as Zometa,alendronate (Fosamax) or risedronate (Actonel), can minimize bone ... - MayoClinic.com

 What I know in my bones  Apr 24, 2005
These drugs include Fosamax and Actonel. They belong to the antiresorptive drug class. ... Newer once-a-week forms of Fosamax,Zometa and Actonel help ease taking them. ... - Vail Daily News,

 Planet Cancer Forums - View Topic

HealthBoards - Bisphosphonates & Rheumatoid Arthritis

... For instance fosamax is not to be taken with meals, but on an empty ... It is used primarily to treat bone cancer patients, so you would find it at ... www.healthboards.com/boards/ showthread.php?goto=lastpost&t=210107 - 59k - Cached - Similar pages

If you are currently taking Zometa you may be at risk of developing osteonecrosis. If you have been injured by Zometa side effects you may be entitled to compensation. For more information about your legal rights contact the offices of

Powell Law Firm, L.C.
is the nation's leading law firm
for litigation regarding Bisphosphonate Complications.
 
for your  free, confidential case evaluation
at toll-free 888-238-1998
Please state your name and phone number
And we will get back with you promptly
or email us at
info@mpowelllaw.com

www.MPowellLaw.com

Accepting Inquiries from the U.S. and Internationally

Every case is different. No specific results are implied. 
 269 South Beverly Drive, Suite 1156, Beverly Hills, CA 90212